Jeffrey Kim, Ph.D.
Jeffrey Kim, Ph.D.
- Stem cells
- Electronic cigarette
- Reference material
Jeffrey Kim, Ph.D. Curriculum Vitae (PDF)
Current research projects:
Effects of Electronic Cigarette Aerosol on Oral Health
The electronic cigarette (EC) industry has been steadily doubling its sales revenue for the past ten years. In the US alone, there are more than 400 companies that are selling thousands of products with little or no federal/local regulation. Many of the commercially available e-liquids and EC devices are made without the benefit of quality standards such as Reference Materials (RMs), as such contaminants and compositional inconsistencies are commonly found. Misleading, inconsistent and contradicting EC research results reinforce an urgent need to establish the scientifically robust standard testing paradigms that can put the array of research findings into a coherent perspective. Dr. Anthony Volpe Research Center researchers have developed e-cigarette testing devices, reference materials and new metrology methods to comprehensively characterize physio-chemical properties of e-cigarette aerosol and its chemical by-products. The ultimate goal of this project is to advance our understanding of potential short-term oral and respiratory health risks and long-term adverse consequences of EC smoking.
Occupational Hazards and Safety in Dental Offices
Nanotechnology enabled products have been rapidly entering the US healthcare sector. Nanomaterials in dentistry have proven to be beneficial in a number of areas including the development of new nano-composites (aka white fillings) with advanced strength, esthetics and service life. However, proof of safety of the nano-composites, Standard Operating Procedures (SOPs) for safe handling, use and disposal, and risk assessment for occupational nanomaterial exposure have not been thoroughly investigated. There is a growing concern that oral health care providers may inhale aerosolized nano-composite particles during routine dental procedures and current Personal Protective Equipment (PPE) such as surgical masks may not provide effective protection against the nano-aerosol. Dr. Anthony Volpe Research Center and NIST researchers are quantifying the physical, chemical, and biological properties of nanocomposite aerosol to advance our understanding of potential short-term health risks and long-term adverse consequences of occupational nano-aerosol exposure.
Proper salivary flow is one of most important and underrated biological processes of oral health. Healthy saliva helps in the remineralization of tooth enamel, lubrication and protection of oral tissues, and reducing the risk for periodontal disease and infection. Dry mouth (xerostomia) has a variety of possible causes: taking medication(s), being the most common cause. Over eighteen hundred drugs, both prescribed and over-the-counter, in more than eighty drug classes cause xerostomia as a side effect and may give rise to other adverse oral manifestations. Although eliminating the offending medication will likely improve salivary flow, stopping the offending medication is often medically not possible. Analysis of our medication-induced xerostomia model may provide valuable data for advancing our understanding of the interaction between salivary gland function and its architecture as well as alternative therapeutic development.
Selected Publications (See NIH Public Access Listing)
O. Khalid, J.J. Kim, L. Duan, M. Hoang, D. Elashoff, Y. Kim: Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs). Genomics Data 2014, 2, 127-131.
- J.J. Kim, L. Duan, T.G. Tu, O. Elie, Y. Kim, N. Mathiyakom, D. Elashoff, Y. Kim: Molecular effect of ethanol during neural differentiation of human embryonic stem cells in vitro. Genomics Data 2014, 2, 139-143.
- J.J. Kim, O. Khalid, L. Duan, R. Kim, D. Elashoff, Y. Kim: Gene expression signatures affected by ethanol and/or nicotine in normal human normal oral keratinocytes (NHOKs). Genomics Data 2014, 2, 156-161.
- M. Hoang, J.J. Kim, Y. Kim, E. Tong, B. Trammell, Y. Liu, S. Shi, C.R. Lee, C. Hong, C.Y. Wang, Y. Kim. Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells. Stem Cell Res. 2016 May 31;17(1):111-121. doi: 10.1016/j.scr.2016.05.021.
- A.M Behrens, J. Kim, N. Hotaling, J.E. Seppala, P. Kofinas, W. Tutak: Rapid fabrication of poly(DL-lactide) nanofiber scaffolds with tunable degradation for tissue engineering applications by air-brushing. Biomed Mater. 2016 Apr 28;11(3):035001.